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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1985-8-15
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pubmed:abstractText |
The expression of L3T4/Lyt-2 on murine T cells has led to the association of these surface markers with recognition of either class II or class I major histo-compatibility complex (MHC) antigens. It has been suggested that these T cell surface antigens interact with nonpolymorphic determinants on MHC antigens. We have examined the role of L3T4 in the recognition of H-2Dd by the T cell hybridoma, 3DT52.5. Mouse L cells transfected with either the H-2Dd gene, or with both the alpha and beta genes of I-Ak and the H-2Dd gene have been used to assess the role of an L3T4/la interaction at varying doses of H-2Dd. A role of L3T4 in activation of 3DT52.5 becomes evident only at limiting doses of antigen. It appears that an L3T4/la interaction can influence T cell function during suboptimal stimulation, implying that the L3T4/la interaction serves to raise the functional affinity of interaction between the T cell and the antigen-bearing cell.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3925069-567555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3925069-6166712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3925069-6170707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3925069-6195085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3925069-6195255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3925069-6200564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3925069-6280871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3925069-6334313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3925069-6413636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3925069-6415170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3925069-6604749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3925069-6607120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3925069-6967414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3925069-6967947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3925069-6975943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3925069-88050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3925069-92524
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
369-74
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3925069-Animals,
pubmed-meshheading:3925069-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:3925069-Antigens, Ly,
pubmed-meshheading:3925069-Antigens, Surface,
pubmed-meshheading:3925069-Histocompatibility Antigens Class II,
pubmed-meshheading:3925069-Hybridomas,
pubmed-meshheading:3925069-L Cells (Cell Line),
pubmed-meshheading:3925069-Lymphocyte Activation,
pubmed-meshheading:3925069-Mice,
pubmed-meshheading:3925069-Receptors, Antigen, T-Cell,
pubmed-meshheading:3925069-T-Lymphocytes,
pubmed-meshheading:3925069-Transfection
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pubmed:year |
1985
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pubmed:articleTitle |
Role of L3T4 in antigen-driven activation of a class I-specific T cell hybridoma.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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