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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1985-8-19
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pubmed:abstractText |
By using both pulse labeling of nascent RNA chains and lactoperoxidase-catalyzed cell surface radioiodination, we examined both the de novo synthesis of mRNA for gamma-chains and the expression of membrane IgG (mIgG) on cells which had been stimulated with LPS plus a T cell supernatant (SN) containing a B cell differentiation factor for IgG1 (BCDF gamma). Our results show that neither nascent mRNA for gamma 1 chains nor mIgG1 can be detected in B lymphocytes until they have been stimulated by both LPS and BCDF gamma-containing T cell SN, and suggest that cell surface expression and secretion of IgG1 are coordinately controlled.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
135
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1465-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3925011-Animals,
pubmed-meshheading:3925011-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:3925011-Antigens, Surface,
pubmed-meshheading:3925011-B-Lymphocytes,
pubmed-meshheading:3925011-Cell Line,
pubmed-meshheading:3925011-Female,
pubmed-meshheading:3925011-Genes, MHC Class II,
pubmed-meshheading:3925011-Immunoglobulin G,
pubmed-meshheading:3925011-Lipopolysaccharides,
pubmed-meshheading:3925011-Lymphocyte Activation,
pubmed-meshheading:3925011-Mice,
pubmed-meshheading:3925011-Mice, Inbred BALB C,
pubmed-meshheading:3925011-Receptors, Antigen, B-Cell,
pubmed-meshheading:3925011-T-Lymphocytes,
pubmed-meshheading:3925011-Transcription, Genetic
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pubmed:year |
1985
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pubmed:articleTitle |
Activation of the gamma 1 gene by lipopolysaccharide and T cell-derived lymphokines containing a B cell differentiation factor for IgG1 (BCDF gamma).
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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