Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-8-9
pubmed:abstractText
The binding of [125I]T4 to serum proteins was studied in human, monkey, cattle, sheep, goat, water buffalo, horse, swine, dog, cat, rabbit, rat, chicken, frog, and salmon. Attempts were made to isolate thyroxine-binding globulin (TBG) and thyroxine-binding prealbumin (TBPA) from serum of all species, utilizing purification methods based on the specific properties of these proteins. TBPA was found to exist in all species examined. The protein was found anodal to albumin only in human, monkey, horse, and chicken. In cattle, swine, dog, cat, rabbit, frog, and salmon, TBPA was found cathodal to albumin, while sheep, goat, water buffalo, and rat had identical mobility of albumin and TBPA. The presence of TBG was demonstrated in larger mammals. In cat, rabbit, rat, chicken, frog, and salmon, TBG could not be demonstrated. The thyroxine-binding capacity of TBPA in serum varied from 1000 to greater than 6000 nmol/l and that of TBG between 150 and 600 nmol/l. TBPA from all species except salmon showed affinity to human retinol-binding protein. The presence of TBPA in all vertebrates suggests prealbumin to be a far more important thyroxine carrier than earlier anticipated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0016-6480
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
360-75
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:3924724-Animals, pubmed-meshheading:3924724-Blood Proteins, pubmed-meshheading:3924724-Buffaloes, pubmed-meshheading:3924724-Bufonidae, pubmed-meshheading:3924724-Cats, pubmed-meshheading:3924724-Cattle, pubmed-meshheading:3924724-Chickens, pubmed-meshheading:3924724-Chromatography, Affinity, pubmed-meshheading:3924724-Dogs, pubmed-meshheading:3924724-Electrophoresis, pubmed-meshheading:3924724-Female, pubmed-meshheading:3924724-Goats, pubmed-meshheading:3924724-Horses, pubmed-meshheading:3924724-Humans, pubmed-meshheading:3924724-Macaca mulatta, pubmed-meshheading:3924724-Male, pubmed-meshheading:3924724-Prealbumin, pubmed-meshheading:3924724-Protein Binding, pubmed-meshheading:3924724-Rabbits, pubmed-meshheading:3924724-Rats, pubmed-meshheading:3924724-Salmon, pubmed-meshheading:3924724-Sheep, pubmed-meshheading:3924724-Species Specificity, pubmed-meshheading:3924724-Swine, pubmed-meshheading:3924724-Thyroxine, pubmed-meshheading:3924724-Thyroxine-Binding Proteins
pubmed:year
1985
pubmed:articleTitle
Thyroid hormone binding in serum of 15 vertebrate species: isolation of thyroxine-binding globulin and prealbumin analogs.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't