Linked Life Data

3924684

Source:http://linkedlifedata.com/resource/pubmed/id/3924684

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1985-8-9
pubmed:abstractText
Rates of production of androgen binding protein (ABP) declined during culture of purified Sertoli cell-enriched aggregates in serum-free minimal essential medium (MEM). This decline was partially prevented by the addition of testosterone to the medium, but not by 17 beta-estradiol addition. The androgen effect was greater in Sertoli cell aggregates in co-culture with peritubular cells than in Sertoli cell preparations depleted of peritubular cells. Initial rates of ABP production by purified Sertoli cell-enriched aggregates were also sustained when preparations were cultured in MEM supplemented with conditioned medium in which peritubular cells had been previously maintained. We interpret data presented to indicate that the stimulatory effects of peritubular cells on functions of Sertoli cells in co-culture, specifically sustained rates of ABP production, are mediated at least partially by component(s) synthesized by peritubular cells and secreted into the medium. We offer the hypothesis that androgens may influence Sertoli cells at two levels: (1) a direct action on Sertoli cells; (2) and indirect influence on Sertoli cells mediated by a direct action on peritubular cells, resulting in the formation of product(s) which modulate the rates of ABP synthesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0303-7207
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
115-22
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Androgen stimulation of Sertoli cell function is enhanced by peritubular cells.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't