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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1985-8-20
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pubmed:abstractText |
Dopamine-depleting brain lesions produced in neonatal rats by intraventricular injection of 6-hydroxydopamine (6-OHDA) are known to increase striatal levels of serotonin by adulthood. We now report that such lesions lead to an increased innervation of the striatum by serotonin-containing neurons from the dorsal raphe nucleus. This hyperinnervation was revealed as a 300% increase in the number of retrogradely labeled neurons in the dorsal raphe after horseradish peroxidase was injected into the adult striatum. The degree of hyperinnervation was reduced sharply when serotonin-depleting brain lesions were given to adult animals that had received 6-OHDA as neonates.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
336
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
354-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3924346-5,7-Dihydroxytryptamine,
pubmed-meshheading:3924346-Afferent Pathways,
pubmed-meshheading:3924346-Animals,
pubmed-meshheading:3924346-Animals, Newborn,
pubmed-meshheading:3924346-Corpus Striatum,
pubmed-meshheading:3924346-Dopamine,
pubmed-meshheading:3924346-Horseradish Peroxidase,
pubmed-meshheading:3924346-Hydroxydopamines,
pubmed-meshheading:3924346-Oxidopamine,
pubmed-meshheading:3924346-Raphe Nuclei,
pubmed-meshheading:3924346-Rats,
pubmed-meshheading:3924346-Rats, Inbred Strains,
pubmed-meshheading:3924346-Serotonin
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pubmed:year |
1985
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pubmed:articleTitle |
Hyperinnervation of the striatum by dorsal raphe afferents after dopamine-depleting brain lesions in neonatal rats.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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