Linked Life Data

3923851

Source:http://linkedlifedata.com/resource/pubmed/id/3923851

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-7-16
pubmed:abstractText
Acetylcholinesterase (AChE) activity was measured in skeletal muscle from susceptible (A/J) and resistant (C57BL/6) mice infected with the Brazil strain (myotropic) of Trypanosoma cruzi. There was a 60% decrease in activity in skeletal muscle obtained from A/J mice 20 days post-infection as compared to controls. There was no decrease in AChE activity in skeletal muscle obtained from infected C57BL/6 mice 20 and 150 days post-infection. Histologic examination of skeletal muscle from infected A/J mice revealed marked necrosis, pseudocysts, and minimal inflammation. Similar examinations in C57BL/6 mice revealed marked inflammation in the absence of necrosis and parasites. These data provide additional biochemical support that denervation hypersensitivity is an important concomitant of Chagas' disease and that it is already present during the acute stage. Additionally, it may support the notion that the presence of the parasite mediates these abnormalities.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0002-9637
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
460-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Acetylcholinesterase levels in skeletal muscle of mice infected with Trypanosoma cruzi.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.