Linked Life Data

3923559

Source:http://linkedlifedata.com/resource/pubmed/id/3923559

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-7-18
pubmed:abstractText
Rats were administered with lithium carbonate (1 mmole/kg), valproate (300 mg/kg) and their combination for 12 days. Rats in the withdrawal group were treated for 10 days, followed by saline for 2 days. Mid-brain tryptophan levels increased in all the groups except lithium-treated rats. The administration of lithium together with valproate decreased tryptophan hydroxylase activity and 5-hydroxytryptamine levels in certain brain regions compared to either treatment alone. Also, the magnitude of valproate-induced 5-hydroxyindoleacetic acid elevation was decreased after combined treatment. Most of the changes observed after combined exposure persisted even after 2 days of treatment withdrawal. It appears from the data that combined administration of the two drugs produces persistent decrease in 5-hydroxytryptamine synthesis and turnover in the brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0278-5846
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
153-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Combined lithium and valproate treatment and subsequent withdrawal: serotonergic mechanism of their interaction in discrete brain regions.
pubmed:publicationType
Journal Article