Linked Life Data

3922881

Source:http://linkedlifedata.com/resource/pubmed/id/3922881

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1985-7-22
pubmed:abstractText
In order to explain the mechanism of enhancing effect of irradiation on IL-2 production, assumption that radio-induced free radicals could act as a signal for mitogenesis and/or increase lipid peroxidation of T lymphocyte membrane phospholipids was made. Thus, production of metabolites of the lipoxygenase pathway in the arachidonic acid (AA) cascade, known to increase T cell proliferation and lymphokine production could be enhanced by irradiation. We have shown that (1) hydroxyl radical scavenger (DMSO) abolished IL-2 production, (2) inhibitor of the lipoxygenase pathway (NDGA) strongly decreased IL-2 production, (3) thin layer chromatography demonstrated a polar metabolite(s) of AA in increasing amounts according to the following order: non-irradiated resting cells, non-irradiated stimulated cells, irradiated resting cells, and irradiated stimulated cells. Investigations are in progress to identify this metabolite.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0165-2478
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
279-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Mechanism of enhancing effect of irradiation on production of IL-2.
pubmed:publicationType
Journal Article, In Vitro