|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6479
|
|
pubmed:dateCreated |
1985-7-10
|
|
pubmed:abstractText |
Hepatitis D virus (delta agent) markers were present in 111 (36%) of 308 intravenous drug abusers who were positive for hepatitis B surface antigen (HBsAg), 52 of these having hepatitis D virus antigenaemia. IgM antibody to hepatitis B core antigen (anti-HBc IgM) was present in 92 out of 95 subjects tested, indicating that hepatitis D virus and hepatitis B virus infections had been acquired simultaneously. Hepatitis D virus markers were present in three out of four patients with fulminant hepatitis, and in 80 of 223 (36%) with mild or moderate hepatitis compared with four of 29 (14%) of those who were asymptomatic. These proportional differences were significant (p less than 0.001). Hepatitis D virus markers were present in twice as many patients positive for anti-HBc IgM requiring admission to hospital with acute hepatitis compared with outpatients attending a drug treatment centre. Tests on one patient showed complete disappearance of HBsAg, but hepatitis D antigen (HDAg or delta antigen) and hepatitis B e antigen (HBeAg) were still present in serum samples. All five patients with chronic active hepatitis had hepatitis D antibody (anti-HD) compared with seven of 24 (29%) with chronic persistent hepatitis (p = 0.008). Blocking anti-HD persisted for long periods after simultaneous infections with hepatitis B virus and hepatitis D virus but at lower titres than in patients with chronic liver disease.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-6127458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-6132106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-6134938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-6137731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-6138670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-6175733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-6363622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-6401506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-6404423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-6417045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-6474132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-6696355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-6736942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-6829551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-6838075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-6852449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-7021574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-7024305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-7152867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3922501-91776
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0267-0623
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
11
|
|
pubmed:volume |
290
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1377-80
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:3922501-Acute Disease,
pubmed-meshheading:3922501-Adult,
pubmed-meshheading:3922501-Female,
pubmed-meshheading:3922501-Hepatitis,
pubmed-meshheading:3922501-Hepatitis B,
pubmed-meshheading:3922501-Hepatitis B Antigens,
pubmed-meshheading:3922501-Hepatitis B Core Antigens,
pubmed-meshheading:3922501-Hepatitis B Surface Antigens,
pubmed-meshheading:3922501-Hepatitis B virus,
pubmed-meshheading:3922501-Hepatitis Viruses,
pubmed-meshheading:3922501-Hepatitis delta Antigens,
pubmed-meshheading:3922501-Humans,
pubmed-meshheading:3922501-Male,
pubmed-meshheading:3922501-Substance-Related Disorders
|
|
pubmed:year |
1985
|
|
pubmed:articleTitle |
Increased severity and morbidity of acute hepatitis in drug abusers with simultaneously acquired hepatitis B and hepatitis D virus infections.
|
|
pubmed:publicationType |
Journal Article
|
