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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1985-5-2
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pubmed:abstractText |
pp60c-src was localized in the cerebellum of developing chicken embryos by immunoperoxidase staining with antisera raised against bacterially expressed pp60v-src. Immunoreactivity (IR) appeared in the cerebellum of the chicken embryos at the time of neuronal differentiation. pp60c-src IR was detected in regions of the developing cerebellum where processes of developing neurons and glia are located. In the early embryo (stage 17), pp60c-src IR was localized in the marginal zone of the cerebellar plate. By stage 40, pp60c-src IR was localized in the process-rich molecular layer of the cerebellum and between the cells of the developing internal granular layer. Cell bodies of cerebellar neurons did not show pp60c-src IR at any stage of development. Mitotically active neuroepithelial cells of the metencephalon did not express pp60c-src before the onset of differentiation in the early embryo, nor did proliferating cells of the external granular layer express pp60c-src at later stages. Although it is not possible to ascertain whether pp60c-src is localized in developing neurons or glia at the light microscope level, the time of its appearance and pattern of distribution in the molecular layer is suggestive of a localization within the developing neuronal processes which compose the bulk of this layer. Biochemical analyses of pp60c-src in the developing cerebellum by the immune complex protein kinase activity and sensitivity of the kinase to inhibition by P1,P4-di(adenosine-5')tetraphosphate confirmed that the expression of pp60c-src coincided with the time of neuronal differentiation. We conclude from these results that in the central nervous systems, pp60c-src may be more important in an aspect of cell differentiation or a mature neuronal function than in the proliferation of neuronal or glial precursors.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3920510-14184856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3920510-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3920510-198667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3920510-205879,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3920510-226956,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3920510-6192323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3920510-6196614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3920510-6198092,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3920510-6261144,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3920510-6304883,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3920510-6320011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3920510-6403227,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3920510-7309923
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27-32
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
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pubmed:year |
1985
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pubmed:articleTitle |
pp60c-src in the developing cerebellum.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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