Linked Life Data

3919309

Source:http://linkedlifedata.com/resource/pubmed/id/3919309

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6006
pubmed:dateCreated
1985-4-19
pubmed:abstractText
T-cell differentiation represents a unique system for studying mechanisms of lymphoid development because it occurs in a segregated site, the thymus, in which distinct subpopulations of thymocytes at various stages of differentiation can be defined on the basis of the differential expression of T-cell surface antigens as well as topography. There is particular interest in thymocyte differentiation because the genotype of radioresistant thymus cells influences the specificity repertoire of the pool of T cells that mature therein: that is, the major histocompatibility complex (MHC) antigens expressed by thymus cells bias the pool of maturing T cells towards recognition of antigens in the 'context' of the products of that MHC haplotype ('thymus education'; refs 1-3). Immature T cells with affinity for thymus MHC antigens are generally thought to undergo a stage of positive selection in the thymus. Here we report that 30% of cells in the least mature adult thymocyte subpopulation yet defined, as well as 50% of immature fetal thymocytes, express receptors for interleukin-2 (IL-2, the T-cell growth factor) without in vitro induction, and will proliferate vigorously in an IL-2-dependent fashion if provided with co-stimulating mitogen.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:volume
314
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
101-3
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Expression and function of interleukin-2 receptors on immature thymocytes.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't