Linked Life Data

3919175

Source:http://linkedlifedata.com/resource/pubmed/id/3919175

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-4-25
pubmed:abstractText
The effect of 5-thio-D-glucose (5-TG) on the hexosemonophosphate shunt (HMS) and on aerobic glycolysis was studied in the mouse small intestine. A time- and dose-dependent inhibition of 14CO2 production from D-[1-14C] or D-[6-14C]glucose was observed by 5-TG in vitro. Using everted rings of intestine, the HMS (measured by the C-1/C-6 ratio of 14CO2 produced) was inhibited approximately 60% relative to control by 11.0 mM 5-TG. The 14CO2 produced from D-[6-14C]glucose was not inhibited markedly until incubations were lengthened to 45 min or longer. The HMS in everted rings from mice treated with 5-TG at 50 mg/kg or 1.5 g/kg i.p. increased 200 or 130%, respectively, compared to saline-treated controls. In contrast, 14CO2 produced from D-[6-14C]glucose was inhibited at both doses. Plasma D-glucose levels were measured 2 hr after treatment and were increased 100% at the low dose or 360% at the high dose, relative to controls (84.1 +/- 3.8 mg/100 ml). This study demonstrated that 5-TG inhibits D-glucose utilization in the mouse small intestine, which may contribute to the diabetogenic effect observed in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
232
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
760-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Action of 5-thio-D-glucose on D-glucose metabolism: possible mechanism for diabetogenic effect.
pubmed:publicationType
Journal Article, In Vitro