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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1985-4-24
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pubmed:abstractText |
The ability of neurotoxic substances to induce selective lesions of the descending monoaminergic pathways in rats was investigated. Saline, 6-hydroxydopamine, 5,6-dihydroxytryptamine, or 5,7-dihydroxytryptamine were administered into the lumbar subarachnoid space through a chronically indwelling catheter. The lesions were evaluated 2-3 weeks later by in vitro uptake of [3H]noradrenaline and [14C]5-hydroxytryptamine into synaptosomal preparations from the frontal cortex, brainstem, cervical spinal cord, and lumbar spinal cord of each animal. There was no difference in uptake between saline-injected and noncatheterized controls and no significant changes in cortical uptake after any of the treatments (dose range of neurotoxins: 0.6-80 micrograms). In the lumbar spinal cord, 6-hydroxydopamine (5-80 micrograms) reduced the [3H]noradrenaline uptake by approximately 90% with no effects on [14C]5-hydroxytryptamine uptake, whereas 5,6-dihydroxytryptamine reduced the uptake of [14C]5-hydroxytryptamine by 90% (20-80 micrograms). [3H]Noradrenaline uptake was unaffected by lower doses of 5,6-dihydroxytryptamine but fell by 45-55% after 40-80 micrograms. 5,7-Dihydroxytryptamine (10-80 micrograms) reduced [3H]noradrenaline uptake by 90-95% and [14C]5-hydroxytryptamine uptake by approximately 80% (5-80 micrograms) in the lumbar cord. It is concluded that intrathecal administration of suitable doses of neurotoxins may produce extensive selective lesions of descending noradrenergic and serotonergic pathways.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5,6-Dihydroxytryptamine,
http://linkedlifedata.com/resource/pubmed/chemical/5,7-Dihydroxytryptamine,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydroxytryptamines,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxydopamines,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-3042
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1156-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3919157-5,6-Dihydroxytryptamine,
pubmed-meshheading:3919157-5,7-Dihydroxytryptamine,
pubmed-meshheading:3919157-Animals,
pubmed-meshheading:3919157-Brain Stem,
pubmed-meshheading:3919157-Dihydroxytryptamines,
pubmed-meshheading:3919157-Dose-Response Relationship, Drug,
pubmed-meshheading:3919157-Frontal Lobe,
pubmed-meshheading:3919157-Hydroxydopamines,
pubmed-meshheading:3919157-Male,
pubmed-meshheading:3919157-Neural Pathways,
pubmed-meshheading:3919157-Norepinephrine,
pubmed-meshheading:3919157-Oxidopamine,
pubmed-meshheading:3919157-Rats,
pubmed-meshheading:3919157-Rats, Inbred Strains,
pubmed-meshheading:3919157-Serotonin,
pubmed-meshheading:3919157-Spinal Cord,
pubmed-meshheading:3919157-Synaptosomes
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pubmed:year |
1985
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pubmed:articleTitle |
Selective neurotoxic lesions of descending serotonergic and noradrenergic pathways in the rat.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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