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rdf:type |
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lifeskim:mentions |
umls-concept:C0020964,
umls-concept:C0025252,
umls-concept:C0026809,
umls-concept:C0032594,
umls-concept:C0042196,
umls-concept:C0439855,
umls-concept:C1136217,
umls-concept:C1167331,
umls-concept:C1545588,
umls-concept:C1707455,
umls-concept:C1998793
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pubmed:issue |
2
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pubmed:dateCreated |
1985-3-21
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pubmed:abstractText |
A methodology for preparing outer membrane proteins (type specific) complexed to group B polysaccharide of Neisseria meningitidis is described. These complexes, low in nucleic acid and lipopolysaccharide content, were immunogenic in mice with induction of humoral antigroup B and antiprotein responses. Immunized mice were also protected against challenge with N. meningitidis group B strains of the same or a different type from that used for vaccination. Both immunity and protection were enhanced when the mice received a secondary immunization with the protein-polysaccharide complex. Additional data have shown the capacity of purified B polysaccharide to induce immunological memory, even though it is incapable of inducing a humoral response when given alone.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-10167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-109466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-1104741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-13436486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-31985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-389783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-408022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-4115393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-416163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-4197754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-4396488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-4398678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-4623401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-4633975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-4977282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-4977283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-6135869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-6187586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-6403470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-6415230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-6437676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-6442212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-6577452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-6790606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-6791823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-6809628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-6811660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-7021555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-7118922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3917979-77885
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0019-9567
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
527-33
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3917979-Animals,
pubmed-meshheading:3917979-Antibodies, Bacterial,
pubmed-meshheading:3917979-Antibody Formation,
pubmed-meshheading:3917979-Bacterial Capsules,
pubmed-meshheading:3917979-Bacterial Outer Membrane Proteins,
pubmed-meshheading:3917979-Bacterial Vaccines,
pubmed-meshheading:3917979-Female,
pubmed-meshheading:3917979-Immunization,
pubmed-meshheading:3917979-Immunologic Memory,
pubmed-meshheading:3917979-Meningococcal Infections,
pubmed-meshheading:3917979-Mice,
pubmed-meshheading:3917979-Neisseria meningitidis,
pubmed-meshheading:3917979-Polysaccharides, Bacterial
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pubmed:year |
1985
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pubmed:articleTitle |
Immunity and protection of mice against Neisseria meningitidis group B by vaccination, using polysaccharide complexed with outer membrane proteins: a comparison with purified B polysaccharide.
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pubmed:publicationType |
Journal Article,
Comparative Study
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