Linked Life Data

3917974

Source:http://linkedlifedata.com/resource/pubmed/id/3917974

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-3-8
pubmed:databankReference
pubmed:abstractText
Studies of rabbit major histocompatibility complex proteins have suggested that rabbits express only a single class I antigen, in contrast to most mouse strains (H-2K, D, and L) and man (HLA-A, -B, and -C), which express three. To explore the significance and the molecular basis of this apparent species difference, we have characterized the expressed class I protein and a corresponding cDNA clone from the rabbit cell line RL-5, which is derived from the inbred B/J rabbit strain. As an extension of these analyses, this report documents the genomic sequence of a gene, designated 19-1, which encodes the same histocompatibility antigen expressed in RL-5. The availability of the corresponding full-length cDNA and amino-terminal protein sequence indicates the fully functional nature of the 19-1 gene and allows presumptive assignment of the transcription start site and delineation of exon/intron boundaries. Comparisons of the rabbit gene with homologous human and mouse sequences reveal a striking similarity between 19-1 and human genes in both exon/intron organization and specific nucleotide sequences; this close similarity allows tentative identification of previously unrecognized transcriptional start sites in the human genes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0093-7711
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-82
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Structure of a functional rabbit class I MHC gene: similarity to human class I genes.
pubmed:publicationType
Journal Article, Comparative Study