Linked Life Data

3912731

Source:http://linkedlifedata.com/resource/pubmed/id/3912731

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
1986-3-31
pubmed:abstractText
19 patients with histologically verified neuroblastoma (n = 18) or suspected of suffering from neuroblastoma (n = 1) were investigated 35 times using 123I- or 131I-labelled meta-iodobenzylguanidine (MIBG) scintigraphy. The purpose of this investigation was to evaluate the accuracy of MIBG imaging in comparison to other diagnostic procedures. X-ray or sonographical procedures depicted 40 neuroblastoma manifestations (primary tumours and metastatic deposits), 36 of these (90%) were found by MIBG scintigraphy. Out of 63 primary neuroblastomas and metastatic deposits, depicted by MIBG scintigraphy, 40 (63%) were detected by corresponding sonographic or x-ray procedures. The 23 neuroblastoma lesions solely depicted by MIBG scans were mainly (87%) situated in the skeletal system. In 12 patients biopsy of the bone marrow confirmed the scintigraphic findings (9 times true positive, 3 times true negative). Three times bone marrow infiltration was not recognized by MIBG scintigraphy. False positive results were not observed. 13 patients were examined before and after chemotherapy; scintigraphic results corresponded to therapy results. Because of the pronounced physiological MIBG uptake by liver tissue, detection of intrahepatic or perihepatic tumour involvement may be difficult. MIBG imaging seems not to be suitable for detecting minimal bone marrow infiltration by neuroblastoma. It is a safe and noninvasive procedure for locating a wide range of neuroblastoma lesions. Its main diagnostic advantage in comparison to x-ray procedures lies in the detection of bone marrow infiltration.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0029-5566
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
222-6
pubmed:dateRevised
2007-1-12
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
[Scintigraphy with radioiodinated meta-iodobenzylguanidine in the diagnosis of neuroblastoma].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract