Linked Life Data

3911886

Source:http://linkedlifedata.com/resource/pubmed/id/3911886

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-2-24
pubmed:abstractText
The effects of continuous intravenous (i.v.) or intraperitoneal (i.p.) infusion of regular insulin on food intake (FI) and body weight (BW) were examined. When rats were infused i.v. with insulin at 0.2 IU/h for 14 days, BW increased until the 10th day and then plateaued, whereas FI was augmented until the end of treatment. The 24-h hyperphagia was mainly due to a diurnal increase in FI--resulting mainly from a large augmentation in meal number, with unchanged meal size. Nocturnal meal number increased and meal size decreased so that nocturnal FI was not affected. At the cessation of infusion, rats became hypophagic and lost weight. Another group of animals, infused with a lower dose (0.1 IU/h), showed that the increases in BW and FI were dose-dependent. Insulin infused (0.2 IU/h) for 14 days via an i.p. catheter increased FI and BW. The 24-h increase in FI was again mainly due to an enhanced diurnal intake, but at the cessation of insulin infusion rats did not lose BW. In rats infused with insulin at 0.1 IU/h for 14 days, BW and FI did not increase. In rats infused via an implanted minipump with insulin at 0.1 IU/h for 7 days, however, BW increased significantly over controls for the first 3 days, without any significant change in FI, the discrepancy between results observed here and other results is discussed, these effects suggest a relative ineffectiveness of the i.p. route compared to i.v.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0195-6663
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
319-29
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Effect of long-term insulin on body weight and food intake: intravenous versus intraperitoneal routes.
pubmed:publicationType
Journal Article, Comparative Study