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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
1986-2-24
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pubmed:abstractText |
The pharmacokinetics of ceftazidime after a 1-g bolus dose were studied in six elderly volunteers and 12 young subjects. Serum and urine samples were collected in serial order for 24 h and assayed by high-pressure liquid chromatography. The ceftazidime renal clearance was reduced in elderly subjects, a symptom related to normal aging of the kidneys. The decrease in volume of distribution in the elderly group may be explained by a reduction in total body water and an increase in fat tissue. Dosage adjustment is probably not necessary for otherwise healthy elderly patients requiring ceftazidime.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0066-4804
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
713-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3911883-Adult,
pubmed-meshheading:3911883-Age Factors,
pubmed-meshheading:3911883-Aged,
pubmed-meshheading:3911883-Ceftazidime,
pubmed-meshheading:3911883-Chromatography, High Pressure Liquid,
pubmed-meshheading:3911883-Creatinine,
pubmed-meshheading:3911883-Female,
pubmed-meshheading:3911883-Half-Life,
pubmed-meshheading:3911883-Humans,
pubmed-meshheading:3911883-Kinetics,
pubmed-meshheading:3911883-Male,
pubmed-meshheading:3911883-Middle Aged,
pubmed-meshheading:3911883-Spectrophotometry, Ultraviolet
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pubmed:year |
1985
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pubmed:articleTitle |
Pharmacokinetics of ceftazidime in elderly volunteers.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
