Linked Life Data

3910044

Source:http://linkedlifedata.com/resource/pubmed/id/3910044

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-2-12
pubmed:abstractText
One of insulin's effects is to stimulate specific mRNA synthesis. Treatment of H4IIE hepatoma cells with 0.01-1.0 nM insulin results in a maximum 10-15 fold increase in the accumulation of a specific mRNA (p33-mRNA) as measured with a cloned cDNA. Concanavalin A, a lectin known to mimic many of insulin's effects, also stimulates the accumulation of p33-mRNA. The effects of both insulin and Con A were blocked by the addition of two RNA synthesis inhibitors, actinomycin D or 5,6 dichloro-1-beta-D-ribofuranosyl-benzimidazole. We therefore suggest that insulin and concanavalin A act to stimulate p33-mRNA synthesis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
133
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1168-74
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
The effects of insulin and concanavalin A on the accumulation of a specific mRNA in rat hepatoma cells.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't