Linked Life Data

3908219

Source:http://linkedlifedata.com/resource/pubmed/id/3908219

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1986-2-19
pubmed:abstractText
It is demonstrated that the level of the action of nitrosomorpholine (NM), diethyl nitrosoamine (DENA) and cyclophosphane (CP) promutagens on bacteria is lowered as a result of the Ames test modification by means of addition of reduced glutathione (G-SH) to the activating mixture. The data are presented on the dependence of this phenomenon on concentration of promutagens and G-SH, the period of bacteria preincubation with the compound under study and the activating mixture as well as on concentration of microsomal protein. No changes in the mutagenic effect of NM, DENA and CP were observed when G-SH was substituted for cysteine in equimolar concentration. This fact points to enzymic mechanism involved in elimination of the damaging effect of mutagenic metabolites of the compounds studied.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0016-6758
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1821-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
[Study of the process of promutagen biotransformation by the Ames test. I. The role of conjugation with glutathione in the modification of the mutagenic activity of nitrosomorpholine, diethylnitrosamine and cyclophosphamide].
pubmed:publicationType
Journal Article, In Vitro, English Abstract