|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0003261,
umls-concept:C0004561,
umls-concept:C0026809,
umls-concept:C0034493,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0051980,
umls-concept:C0301625,
umls-concept:C0815089,
umls-concept:C1442792,
umls-concept:C1880022
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1986-1-28
|
|
pubmed:abstractText |
Mice treated from birth with polyclonal, crude or affinity purified rabbit or monoclonal rat anti-mouse IgM antibodies [b-7-6 and C-2-23: Eur. J. Immunol. 14: 753-757, 1984] were found to be heavily suppressed with respect to B-cell activities. Crude or affinity purified rabbit or monoclonal rat anti-mouse IgM gave comparable results as follows: serum IgM was below detectable levels; serum IgG was reduced to about 1-3% of normal levels; free anti-IgM was always detectable; IgM and/or kappa-light-chain positive cells as well as IgM-secreting cells were absent in various lymphoid organs; the B-cell mitogen lipopolysaccharide was unable to induce proliferative responses; primary antibody responses could not be induced against sheep red blood cells and phosphorylcholine; lymphoid organs were reduced in size and B-cell areas were not populated with lymphocytes; besides a 40% reduction in absolute lymphocyte numbers in the blood, we found increased platelet counts and a 10% eosinophilia in anti-IgM-treated mice.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0304-3568
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
53
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
301-13
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:3908182-Animals,
pubmed-meshheading:3908182-Antibodies, Anti-Idiotypic,
pubmed-meshheading:3908182-Antibodies, Monoclonal,
pubmed-meshheading:3908182-Antibody Formation,
pubmed-meshheading:3908182-B-Lymphocytes,
pubmed-meshheading:3908182-Bone Marrow Cells,
pubmed-meshheading:3908182-Hemolytic Plaque Technique,
pubmed-meshheading:3908182-Immune Sera,
pubmed-meshheading:3908182-Immune Tolerance,
pubmed-meshheading:3908182-Immunoglobulin G,
pubmed-meshheading:3908182-Immunoglobulin M,
pubmed-meshheading:3908182-Lymph Nodes,
pubmed-meshheading:3908182-Lymphocyte Activation,
pubmed-meshheading:3908182-Mice,
pubmed-meshheading:3908182-Mice, Inbred BALB C,
pubmed-meshheading:3908182-Mice, Inbred C57BL,
pubmed-meshheading:3908182-Rabbits,
pubmed-meshheading:3908182-Rats,
pubmed-meshheading:3908182-Spleen
|
|
pubmed:year |
1985
|
|
pubmed:articleTitle |
Suppression of B cell development and antibody responses in mice with polyclonal rabbit and monoclonal rat anti-IgM antibodies. I. Characterization of the suppressed state.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
