Linked Life Data

3906273

Source:http://linkedlifedata.com/resource/pubmed/id/3906273

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-12-30
pubmed:abstractText
Hepatic insufficiency associated with the multiple-system organ-failure (MSOF) syndrome is a frequent sequellae of sepsis and severe trauma. Although its etiology is poorly understood, there is a growing literature suggesting that it may be mediated in part by secretory products of cells of monocyte/macrophage lineage including Kupffer cells. Several investigators have reported in vitro macrophage/Kupffer cell-mediated cytotoxicity toward target cells following appropriate stimulation. In addition, in vivo hepatocyte toxicity has been documented following activation of the reticuloendothelial system. The role of several secretory products including active oxygen intermediates, neutral proteases, and interleukin 1 in this cell-mediated model of hepatocellular modulation is reviewed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
555-63
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Macrophage-mediated modulation of hepatic function in multiple-system failure.
pubmed:publicationType
Journal Article, Review