|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004057,
umls-concept:C0005821,
umls-concept:C0012582,
umls-concept:C0014098,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0023981,
umls-concept:C0086418,
umls-concept:C0282440,
umls-concept:C0333205,
umls-concept:C1096777,
umls-concept:C1274040,
umls-concept:C1280500,
umls-concept:C1518988,
umls-concept:C1522492
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1985-12-5
|
|
pubmed:abstractText |
A prospective randomized double-blind trial was conducted to study the effect of platelet-inhibiting drugs on mural thrombus formation after carotid endarterectomy. Twenty-two patients undergoing carotid endarterectomy were randomly assigned to perioperative administration of an aspirin/dipyridamole combination or a placebo, and the postoperative results were compared. Autologous indium-111-labeled platelets were injected postoperatively, and platelet deposition was measured at the endarterectomy site. It was found that the treated group had a significant reduction in platelet accumulation compared with the placebo group. The results suggest that the perioperative use of aspirin/dipyridamole may reduce the risk of operative stroke and the long-term risk of repeat carotid stenosis.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0022-3085
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
63
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
693-8
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:3903068-Aged,
pubmed-meshheading:3903068-Aspirin,
pubmed-meshheading:3903068-Blood Platelets,
pubmed-meshheading:3903068-Carotid Arteries,
pubmed-meshheading:3903068-Carotid Artery Diseases,
pubmed-meshheading:3903068-Cerebrovascular Disorders,
pubmed-meshheading:3903068-Clinical Trials as Topic,
pubmed-meshheading:3903068-Constriction, Pathologic,
pubmed-meshheading:3903068-Dipyridamole,
pubmed-meshheading:3903068-Drug Therapy, Combination,
pubmed-meshheading:3903068-Endarterectomy,
pubmed-meshheading:3903068-Female,
pubmed-meshheading:3903068-Humans,
pubmed-meshheading:3903068-Intraoperative Period,
pubmed-meshheading:3903068-Male,
pubmed-meshheading:3903068-Middle Aged,
pubmed-meshheading:3903068-Postoperative Complications,
pubmed-meshheading:3903068-Prospective Studies,
pubmed-meshheading:3903068-Random Allocation,
pubmed-meshheading:3903068-Thrombosis
|
|
pubmed:year |
1985
|
|
pubmed:articleTitle |
Effect of perioperative platelet inhibition on postcarotid endarterectomy mural thrombus formation. Results of a prospective randomized controlled trial using aspirin and dipyridamole in humans.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
