Linked Life Data

3901078

Source:http://linkedlifedata.com/resource/pubmed/id/3901078

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-10-28
pubmed:abstractText
This review is concerned with the mechanical forces that cause epithelial sheets to invaginate during morphogenesis. Interest in this problem is currently increasing and a variety of models, each with a different emphasis, have been formulated to explain mechanical aspects of epithelial folding. A critical evaluation of the experimental evidence bearing on this problem leads to the following conclusions. (1) The most popular model of invagination, one based on microfilament-mediated cell shape change, should be re-examined, given the limitations of the experimental evidence usually offered in its support. Recent experiments with permeabilized epithelia offer a promising approach for confirming the validity of this model. (2) Current hypotheses based on disparities in the adhesive properties of epithelial cells are consistent with available data, but appear to be impossible to test directly at this time. (3) There is evidence that suggests that cell growth and division are involved in invagination during the branching morphogenesis of some epithelio-mesenchymal organs, but it has been shown that these processes are not involved in other cases. (4) Recent studies demonstrate that some epithelial invaginations are accompanied by movements of cells, both in the form of rearrangement (exchange of nearest neighbors) and involution (flow of surrounding cells into the invaginating region). (5) A general conclusion that may be drawn from the data now available is that several different mechanisms of epithelial folding operate during morphogenesis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0033-5770
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
289-307
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Mechanisms of epithelial invagination.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review