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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1985-11-21
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pubmed:abstractText |
Previous studies have shown that lymphocytes from renal allografted patients with a good functioning graft display donor-specific cell-mediated lympholysis nonreactivity (CML-NR) in vitro. To define whether the HLA system influences the occurrence of the CML-NR, immunogenetic studies were carried out. Posttransplant lymphocytes derived from CML-NR patients were stimulated in vitro with lymphocytes from unrelated healthy blood donors, who were selected for the presence or absence of kidney donor-specific HLA antigens. The presentation of kidney donor-specific HLA-B (and -C) antigens on the lymphocytes of unrelated blood donors resulted in cytolytic nonresponsiveness, whereas presentation of the kidney donor-specific HLA-A locus antigens on lymphocytes of the unrelated blood donors revealed no cytolytic nonresponsiveness. The results, as displayed by posttransplant lymphocytes of renal allografted patients, demonstrate that the kidney donor HLA-B (and -C) antigens are responsible for the in vitro-observed, donor-specific CML-NR. Consequently, presentation of cells from panel members matched to the kidney donor at the HLA-B locus suppresses the response towards HLA-A locus antigens. The in vitro-observed cytolytic nonresponsiveness appeared not to be due to an absence of specific cytotoxic T lymphocytes, because the nonresponsiveness can be abrogated by addition of exogenous IL 2.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
135
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3082-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3900203-Clone Cells,
pubmed-meshheading:3900203-Cytotoxicity, Immunologic,
pubmed-meshheading:3900203-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:3900203-HLA Antigens,
pubmed-meshheading:3900203-HLA-A Antigens,
pubmed-meshheading:3900203-HLA-B Antigens,
pubmed-meshheading:3900203-HLA-C Antigens,
pubmed-meshheading:3900203-Humans,
pubmed-meshheading:3900203-Immunity, Cellular,
pubmed-meshheading:3900203-Kidney Transplantation,
pubmed-meshheading:3900203-Lymphocyte Activation,
pubmed-meshheading:3900203-Spleen,
pubmed-meshheading:3900203-Tissue Donors
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pubmed:year |
1985
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pubmed:articleTitle |
HLA regulates postrenal transplant CML nonreactivity.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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