Linked Life Data

3899099

Source:http://linkedlifedata.com/resource/pubmed/id/3899099

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
1985-10-7
pubmed:abstractText
Evidence is presented for two new forms of mouse liver and kidney aldehyde reductase activity (designated AHR-3 and AHR-4) resolved using cellulose acetate electrophoresis zymogram techniques and stained by glyceraldehyde and NADPH as substrate and coenzyme, respectively. Activity variants were observed for those isozymes among inbred strains of mice and used in a genetic analyses to support a proposal for two new genetic loci (Ahr-3 and Ah-4) which control the activity phenotype for these isozymes. Segregation analysis indicated that these loci are separately localized on the mouse genome, with Ahr-3 positioned on the distal end of chromosome 7. Liver AHR-2 (or hexonate dehydrogenase) exhibited no detectable phenotypic variation among the 44 inbred strains of mice examined. The AHR-3 and AHR-4 isozymes were readily distinguished from AHR-1 [or aldehyde reductase A2, described previously by Duley and Holmes (Biochem. Genet. 20:1067, 1982)], hexonate dehydrogenase (AHR-2), and alcohol dehydrogenase A2 in terms of their differential substrate, coenzyme, and inhibitor specificities.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-2928
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
483-96
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Aldehyde reductase isozymes in the mouse: evidence for two new loci and localization of Ahr-3 on chromosome 7.
pubmed:publicationType
Journal Article