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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1985-10-10
|
| pubmed:abstractText |
Immunohistochemical demonstration of glial fibrillary acidic protein (GFAP) was performed in human, sheep, rat and guinea pig pineal bodies to determine if there were species differences. Specialized "basket-like" arrangements of many GFAP-positive astrocytic processes were shown around sheep pinealocytes. Human pineals contained scattered astrocytic cell bodies and a moderate number of GFAP-positive astrocytic processes which, as in sheep, also surrounded pinealocytes, but without the dense basket-like arrangements. In both species GFAP-positive fibers were concentrated at the periphery of pseudolobules and around blood vessels. Rat and guinea pig pineals contained only rare astrocytic cell bodies and few GFAP-positive fibers throughout the glands, but had a concentration of parallel GFAP-positive fibers at the stalk. GFAP-positive fibers in human and sheep pineals may be derived from both intra- and extraglandular sites, whereas in rodents only rare processes appear to be derived from within the gland. Astrocytes may play a role in modulation of pineal indoleamines and norepinephrine, and the species differences observed suggest that this effect may be important in sheep and human pineals but not in rodents.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0022-3069
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
44
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
486-95
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3897467-Adult,
pubmed-meshheading:3897467-Aged,
pubmed-meshheading:3897467-Animals,
pubmed-meshheading:3897467-Astrocytes,
pubmed-meshheading:3897467-Female,
pubmed-meshheading:3897467-Glial Fibrillary Acidic Protein,
pubmed-meshheading:3897467-Guinea Pigs,
pubmed-meshheading:3897467-Histocytochemistry,
pubmed-meshheading:3897467-Humans,
pubmed-meshheading:3897467-Immunoenzyme Techniques,
pubmed-meshheading:3897467-Male,
pubmed-meshheading:3897467-Microtomy,
pubmed-meshheading:3897467-Middle Aged,
pubmed-meshheading:3897467-Paraffin,
pubmed-meshheading:3897467-Pineal Gland,
pubmed-meshheading:3897467-Rats,
pubmed-meshheading:3897467-Sheep,
pubmed-meshheading:3897467-Species Specificity
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Immunocytochemistry of pineal astrocytes: species differences and functional implications.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|