Linked Life Data

3896186

Source:http://linkedlifedata.com/resource/pubmed/id/3896186

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1985-9-26
pubmed:abstractText
Because of the many differences among studies of single-dose antimicrobial therapy for uncomplicated urinary tract infection in women, we reviewed the 14 randomized controlled trials on this subject. Twelve concluded that single-dose therapy was as effective as conventional multiple-dose therapy. Although the studies were carefully conducted, none both reported and ascertained in a blinded manner the incidence of adverse drug reactions. Also, no study included enough patients to prevent type II error. To circumvent the problem of having too few patients in each study, we used a rational strategy for pooling the data from the reviewed studies. Single-dose amoxicillin (3 g) was significantly less effective than conventional multidose therapy (69% vs 84%), while single-dose sulfamethoxazole-trimethoprim (two or three double-strength tablets) was indistinguishable from multidose, although there still were too few patients to exclude type II error. More research on this subject is needed with greater attention to sample size and blinded ascertainment of adverse reactions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0003-9926
pubmed:author
pubmed:issnType
Print
pubmed:volume
145
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1672-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Single-dose antibiotic treatment for uncomplicated urinary tract infections. Less for less?
pubmed:publicationType
Journal Article, Clinical Trial, Review