Linked Life Data

3895022

Source:http://linkedlifedata.com/resource/pubmed/id/3895022

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-9-16
pubmed:abstractText
The effect of exogenous progesterone (P) on the corpus luteum function (in terms of the secretion of P and 20-alpha-dihydroprogesterone (DHP), on the secretion of prolactin (Prl) and on the pituitary responsiveness to LHRH was studied in pseudopregnant (PSP) rats kept in alternating and constant lighting conditions (LD-PSP and LL-PSP rats, respectively). Rats were rendered pseudopregnant by appropriately timed stimulation of the cervix uteri (LL rats first received an ovulatory dose of hCG). LH responses were induced by constant rate infusion of LHRH (104 ng/h for 21 h). P was delivered by subcutaneously inserted Silastic implants; control rats received sham implants. In both LD-and LL-PSP rats the plasma P and DHP levels were high on day 8 of PSP. On day 12, however, the plasma P levels had fallen but the DHP levels had risen, demonstrating that between days 8 and 12 functional luteolysis had occurred and that neither the production of P and DHP, nor the timing of luteolysis are under the control of the lighting conditions. On day 12 of PSP the pituitary responsiveness to LHRH was much higher than on day 8. Moreover, on days 8/9 of PSP peaks of Prl were seen in all rats, but on days 11/12 such peaks were largely absent. In LD-PSP rats 'nocturnal' Prl peaks were seen on days 8/9 in all 9 experimental animals, but 'diurnal' peaks were seen in only 4 of these animals. Also, the diurnal peaks were on average much lower than the nocturnal peaks.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
52-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Progesterone and the control of functional luteolysis, of secretion of prolactin and of pituitary LHRH responsiveness. A study with pseudopregnant rats kept in alternating and constant lighting conditions.
pubmed:publicationType
Journal Article