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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1980-2-26
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pubmed:abstractText |
The separation of mouse splenic T lymphocytes into distinct subpopulations by fractionation on histamine-rabbit serum albumin Sepharose (H-RSAS) columns has been described. The H-RSAS-adherent T cells have been attributed regulatory functions associated with B cell activity, T cell-mediated cytotoxicity and the secretion of mediators such as immuno-interferon. The possibility that H-RSAS-adherent T cells exert a similar regulatory effect on an in vitro parameter of T cell-mediated immunity was investigated by assaying the production of leucocyte migration inhibition factor (LIF) in human blood samples, using the agarose droplet method. Phytohaemagglutinin (PHA) and BCG-purified protein derivative (PPD) were used as stimulants of LIF secretion which was measured as a percentage of inhibition of linear leucocytic migration. In normal individuals a highly significant (P less than 0.001) decrease was demonstrated in the production of LIF by peripheral blood leucocytes depleted of H-RSAS-adherent cells. Migration inhibition dropped from 36 +/- 11.7% to 21.2 +/- 12.9% in eighteen cases tested with PHA and from 29.3 +/- 11.7% to 17.2 +/- 9.8% in twelve cases tested with PPD. These results suggest the existence of a lymphocytic subpopulation involved in LIF production which expresses histamine receptors.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-1080834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-1085324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-1086886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-1095211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-133010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-137269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-14978856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-184034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-300387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-302190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-324636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-334402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-4120226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-4145025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-4265964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-4269812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-4563150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-4598645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-4602662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-55418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/389498-641348
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
562-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:389498-Cell Adhesion,
pubmed-meshheading:389498-Cell Separation,
pubmed-meshheading:389498-Child,
pubmed-meshheading:389498-Child, Preschool,
pubmed-meshheading:389498-Histamine,
pubmed-meshheading:389498-Humans,
pubmed-meshheading:389498-Infant,
pubmed-meshheading:389498-Leukocyte Migration-Inhibitory Factors,
pubmed-meshheading:389498-Leukocytes,
pubmed-meshheading:389498-Lymphokines,
pubmed-meshheading:389498-Phytohemagglutinins,
pubmed-meshheading:389498-Sepharose,
pubmed-meshheading:389498-T-Lymphocytes,
pubmed-meshheading:389498-Tuberculin
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pubmed:year |
1979
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pubmed:articleTitle |
Participation of a histamine-Sepharose-adherent subpopulation of human mononuclear cells in the production of leucocyte migration inhibition factor (LIF) in healthy children.
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pubmed:publicationType |
Journal Article
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