Linked Life Data

3891494

Source:http://linkedlifedata.com/resource/pubmed/id/3891494

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-7-31
pubmed:abstractText
The lectin peanut agglutinin binds to mucin secreted by neoplastic but not normal human colonic epithelial cells. Peanut agglutinin was found to bind to mucin secreted by experimentally induced neoplasms in the distal colons of CF-1 mice, but not in the distal colons of control animals. Serial examination of colonic tissues after exposure to carcinogen has revealed the "cancer-associated" mucin in histologically normal but potentially premalignant epithelium. Thus, in the chemical carcinogen-rodent model, a diffuse alteration in glycoprotein structure is found in that part of the murine colon that subsequently develops cancer, and this precedes the appearance of neoplastic tissue. Changes in mucin structure may prove to be useful in the identification of premalignant gastrointestinal epithelium in certain humans at high risk for colon cancer.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0016-5085
pubmed:author
pubmed:issnType
Print
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-37
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Binding of lectins to goblet cell mucin in malignant and premalignant colonic epithelium in the CF-1 mouse.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.