Linked Life Data

3889457

Source:http://linkedlifedata.com/resource/pubmed/id/3889457

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-7-24
pubmed:abstractText
The process of immortalization of cultured rat liver epithelial-like cells from JAR-2 rats was studied by time-lapse cinemicrography. This process was shown to be multistep. First (in the F-phase), cells were similar to those in a finitely proliferative population. Most cells terminated their proliferative life in the F-phase, while a few gained additional proliferative potential and subsequently entered into the T (transitional)-phase. In the T-phase, a population of cells maintained proliferative potential with a large fluctuation: Some cells further gained additional proliferative potential while others lost it. After a period in the T-phase, continuously dividing cells emerged (in the I-phase). The interphase period of the dividing cells in both the T- and the F-phases showed cells to distribute exponentially, consistent with transitional probability models. However, cells in the I-phase were distributed much more narrowly and were frequently close to a normal distribution. Hypothetical mechanisms of immortalization were presented on the basis of these observations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0027-8874
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1223-32
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Immortalization in culture of rat cells: a genealogic study.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't