Linked Life Data

3889189

Source:http://linkedlifedata.com/resource/pubmed/id/3889189

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-7-25
pubmed:abstractText
A serological antibody competition test (SACT) using a murine anti-Mycobacterium leprae-specific monoclonal antibody (ML04) has been evaluated in 96 untreated leprosy patients and 128 control subjects. The test is based on the competitive inhibition by antibodies from human test sera of the binding of the specific 125I-ML04 murine monoclonal antibody to M. leprae soluble antigen coated microtiter plates. Along the spectrum of the disease, SACT positivity was observed in 100% of LL-BL, 87.5% of BB, and 46.7% of the TT-BT groups of patients. Moreover, 46.4% of apparently healthy household family contacts of multibacillary leprosy cases were also antibody positive. Sera from 15 contacts of paucibacillary leprosy cases as well as from 85 various nonleprosy subjects (tuberculosis, autoimmune disease, cancer, and healthy) were all found to be negative. These results satisfy the requirements of a leprosy-specific serodiagnostic test. The striking increase of antibody titer in all of the LL/BL patients indicates a potential prognostic utility of this test for the lepromatous shift of the disease. The observed positivity in a fraction of healthy leprosy contacts still requires prospective evaluation of disease incidence in a larger test sample.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0148-916X
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
33-8
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Serological survey of leprosy and control subjects by a monoclonal antibody-based immunoassay.
pubmed:publicationType
Journal Article