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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1985-6-27
|
pubmed:abstractText |
Sixty-six post-menopausal women with metastatic breast cancer were randomised to receive tamoxifen or tamoxifen with aminoglutethimide. The women in the tamoxifen group were virtually free of toxicity, whilst 45% of patients in the aminoglutethimide group had toxicity and 13% discontinued the drug because of this. Responses were seen in 19% of patients receiving tamoxifen alone and 23% of those receiving both drugs. There is no indication that the increased toxicity seen with the addition of aminoglutethimide to tamoxifen in this situation is justified by an increased response rate.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0344-5704
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
14
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
272-3
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:3888433-Aged,
pubmed-meshheading:3888433-Aminoglutethimide,
pubmed-meshheading:3888433-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:3888433-Breast Neoplasms,
pubmed-meshheading:3888433-Clinical Trials as Topic,
pubmed-meshheading:3888433-Female,
pubmed-meshheading:3888433-Humans,
pubmed-meshheading:3888433-Menopause,
pubmed-meshheading:3888433-Middle Aged,
pubmed-meshheading:3888433-Random Allocation,
pubmed-meshheading:3888433-Tamoxifen
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pubmed:year |
1985
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pubmed:articleTitle |
A randomised trial of tamoxifen versus tamoxifen with aminoglutethimide in post-menopausal women with advanced breast cancer.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|