Linked Life Data

3888202

Source:http://linkedlifedata.com/resource/pubmed/id/3888202

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-6-17
pubmed:abstractText
Islet cell surface antibodies (ICSA) raised by immunizing rabbits with pancreatic islet cell suspensions were characterized with respect to some aspects of their influence on neonatal rat islet cells or isolated islets of Langerhans. The removal of unspecific cytotoxic factors by absorption with liver powder and spleen cells was reflected in changes of the antibody binding pattern to islet cells demonstrated by flow-cytometric analysis as well as the corresponding 51Cr-release from prelabelled islet cells. Using neonatal rat pancreatic islets as a target, fresh ICSA-positive serum provokes a beta-cell specific insulin leakage in a concentration dependent manner. In contrast to heat-inactivated antiserum the complement-mediated cytotoxic effect of rabbit anti-rat islet cell surface antiserum seems to have its morphological expression also in alterations of the islet surface structure as revealed by scanning electron microscopy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0232-766X
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
107-15
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Effect of islet cell surface antibodies on neonatal rat pancreatic islet cells or isolated islets of Langerhans in vitro.
pubmed:publicationType
Journal Article