| pubmed-article:3887938 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3887938 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:3887938 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3887938 | lifeskim:mentions | umls-concept:C0205161 | lld:lifeskim |
| pubmed-article:3887938 | lifeskim:mentions | umls-concept:C0029161 | lld:lifeskim |
| pubmed-article:3887938 | pubmed:issue | 5 Pt 1 | lld:pubmed |
| pubmed-article:3887938 | pubmed:dateCreated | 1985-6-14 | lld:pubmed |
| pubmed-article:3887938 | pubmed:abstractText | The effect of intravenous glucose or tolbutamide administration on plasma glucose and insulin levels was compared with that following spontaneous ingestion of glucose in freely moving 6- to 7-wk- and 13- to 14-wk-old lean and obese (fa/fa) rats. Irrespective of age, the obese rats had a normal blood glucose tolerance when glucose or tolbutamide load was given intravenously, whereas the glucose ingestion [oral glucose tolerance test (OGTT) caused a marked glucose intolerance that became more pronounced with the duration of the syndrome. This suggests that factors other than insulin resistance could play a role in the occurrence of abnormal OGTT in obese rats. When blood insulin levels were expressed as percent change over base line and when compared with age-matched normal rats, the 6- to 7-wk obese rats showed a normal and even higher beta-cell responsiveness to intravenous or oral glucose as well as to tolbutamide. In contrast, the 13- to 14-wk obese rats presented a decreased beta-cell responsiveness to all such stimuli. Thus the beta-cell function of obese rats worsens with time. Inasmuch as 13- to 14-wk-old obese fa/fa rats have insulin resistance, high basal glycemia, and abnormal oral glucose tolerance, they can be viewed as a potential model of type II diabetes. | lld:pubmed |
| pubmed-article:3887938 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3887938 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3887938 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3887938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3887938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3887938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3887938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3887938 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3887938 | pubmed:month | May | lld:pubmed |
| pubmed-article:3887938 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:3887938 | pubmed:author | pubmed-author:JeanrenaudBB | lld:pubmed |
| pubmed-article:3887938 | pubmed:author | pubmed-author:IonescuEE | lld:pubmed |
| pubmed-article:3887938 | pubmed:author | pubmed-author:SauterJ FJF | lld:pubmed |
| pubmed-article:3887938 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3887938 | pubmed:volume | 248 | lld:pubmed |
| pubmed-article:3887938 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3887938 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3887938 | pubmed:pagination | E500-6 | lld:pubmed |
| pubmed-article:3887938 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:3887938 | pubmed:meshHeading | pubmed-meshheading:3887938-... | lld:pubmed |
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| pubmed-article:3887938 | pubmed:meshHeading | pubmed-meshheading:3887938-... | lld:pubmed |
| pubmed-article:3887938 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3887938 | pubmed:articleTitle | Abnormal oral glucose tolerance in genetically obese (fa/fa) rats. | lld:pubmed |
| pubmed-article:3887938 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3887938 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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