Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
1985-6-12
pubmed:abstractText
This minireview surveys recent progress in the field of immunoregulation by the central nervous system. Representative findings from human and animal studies show evidence for significant immunosuppression in states of psychic distress. Mechanisms of immunomodulation are discussed in light of data implicating neuroendocrine, genetic, neuroanatomical, and learning factors. Evidence for reciprocal modulation of immune and nervous systems is considered. A simple hierarchical model proposes traits that are acted on by environment and experience to produce chronic states of mental health vs. psychic distress; these states determine baseline immunocompetence and response to afferent signals during acute immune challenge. Multidisciplinary interest in psychoneuroimmunology has accelerated the rate of inquiry into the mechanistic details of immunoregulation and has generated new appreciation for the pervasive effects of mental status on physiologic homeostasis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1799-812
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:3887082-Adaptation, Psychological, pubmed-meshheading:3887082-Animals, pubmed-meshheading:3887082-Antibody Formation, pubmed-meshheading:3887082-Autoimmune Diseases, pubmed-meshheading:3887082-Brain, pubmed-meshheading:3887082-Catecholamines, pubmed-meshheading:3887082-Cytotoxicity, Immunologic, pubmed-meshheading:3887082-Depressive Disorder, pubmed-meshheading:3887082-Endorphins, pubmed-meshheading:3887082-Feedback, pubmed-meshheading:3887082-Glucocorticoids, pubmed-meshheading:3887082-HLA Antigens, pubmed-meshheading:3887082-Humans, pubmed-meshheading:3887082-Hypothalamo-Hypophyseal System, pubmed-meshheading:3887082-Immune Tolerance, pubmed-meshheading:3887082-Immunity, Cellular, pubmed-meshheading:3887082-Immunocompetence, pubmed-meshheading:3887082-Lymphocytes, pubmed-meshheading:3887082-Mental Disorders, pubmed-meshheading:3887082-Models, Biological, pubmed-meshheading:3887082-Models, Psychological, pubmed-meshheading:3887082-Phagocytes, pubmed-meshheading:3887082-Pituitary-Adrenal System, pubmed-meshheading:3887082-Stress, Psychological
pubmed:year
1985
pubmed:articleTitle
Psychic distress and the immune response.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't