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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1985-5-23
|
| pubmed:abstractText |
In advanced ovarian carcinoma operation alone does not give any change of permanent cure. Therefore an additional treatment is necessary. From 1977 to 1980 we performed a prospective random study about the significance of postoperative radio- and chemotherapy (group A, n = 20) versus combined longterm chemotherapy (group B, n = 24) in ovarian carcinoma stage III. Radical operation was possible in 82% of all cases. 8 of them (18%) occasionally a second-look operation (A = 2, B = 6). Radiotherapy was a whole abdomen irradiation (Co60-teletherapy-40 Gy in two series, pelvis additional 20 Gy) by means of open field technique. Cyclophosphamide, methotrexate, 5-fluorouracile and vinblastine were used for the purpose of chemotherapy. The survival time was not significantly prolonged in group B (20,4 months) compared to group A (13,9 months). 44% (B) survived three years contrary to 36% (A); after four and five years survival rates are equal in both groups (A = 36%, B = 37%). Thus additional radiotherapy does not improve survival rate. On the other hand there are considerable side-effects and tolerance against chemotherapy is diminished. That is why a general radiotherapy is not recommendable in the present modification.
|
| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0044-4197
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
107
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
237-44
|
| pubmed:dateRevised |
2008-2-11
|
| pubmed:meshHeading |
pubmed-meshheading:3885634-Adolescent,
pubmed-meshheading:3885634-Adult,
pubmed-meshheading:3885634-Aged,
pubmed-meshheading:3885634-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:3885634-Castration,
pubmed-meshheading:3885634-Clinical Trials as Topic,
pubmed-meshheading:3885634-Combined Modality Therapy,
pubmed-meshheading:3885634-Cyclophosphamide,
pubmed-meshheading:3885634-Female,
pubmed-meshheading:3885634-Fluorouracil,
pubmed-meshheading:3885634-Humans,
pubmed-meshheading:3885634-Hysterectomy,
pubmed-meshheading:3885634-Methotrexate,
pubmed-meshheading:3885634-Middle Aged,
pubmed-meshheading:3885634-Neoplasm Staging,
pubmed-meshheading:3885634-Ovarian Neoplasms,
pubmed-meshheading:3885634-Prognosis,
pubmed-meshheading:3885634-Radiotherapy Dosage,
pubmed-meshheading:3885634-Vincristine
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
[Postoperative radio- and/or chemotherapy in ovarian stage III cancers. Results of a prospective randomized study].
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
English Abstract,
Randomized Controlled Trial
|