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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1985-3-27
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pubmed:abstractText |
Pluripotent stem cells from human bone marrow can be identified in culture by their ability to form multilineage hematopoietic colonies containing different myeloid lineages and T cells of different phenotypes. The observation of a common progenitor of myeloid and lymphoid cells in normal and disturbed hematopoiesis prompted the question of whether B cells are part of the differentiation program of stem cells. The availability of hybridomas of azaguanine-resistant T-cell lines secreting monoclonal growth factors for B cells and clinical conditions that are considered to originate from malignant B cells might facilitate this investigation. We were able to identify surface immunoglobulin and B-cell-associated antigen-positive cells within such colonies, indicating that B cells are generated from a myelolymphopoietic stem cell. This report describes the presence of B cells in these colonies derived from bone marrow cells of patients with non-Hodgkin lymphoma.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3883349-140917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3883349-351892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3883349-4166831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3883349-435638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3883349-4527990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3883349-4822532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3883349-6163824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3883349-6801660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3883349-6934014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3883349-6937220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3883349-6950947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3883349-6972790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3883349-6979753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3883349-6982734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3883349-7041173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3883349-719177
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
883-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3883349-B-Lymphocytes,
pubmed-meshheading:3883349-Bone Marrow Cells,
pubmed-meshheading:3883349-Hematopoietic Stem Cells,
pubmed-meshheading:3883349-Humans,
pubmed-meshheading:3883349-Immunoenzyme Techniques,
pubmed-meshheading:3883349-Immunoglobulin D,
pubmed-meshheading:3883349-Immunoglobulin M,
pubmed-meshheading:3883349-Lymphoma,
pubmed-meshheading:3883349-Receptors, Antigen, B-Cell
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pubmed:year |
1985
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pubmed:articleTitle |
Identification of B cells in multilineage hematopoietic colonies derived from cells of patients with lymphocytic lymphoma.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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