Linked Life Data

3882311

Source:http://linkedlifedata.com/resource/pubmed/id/3882311

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-3-28
pubmed:abstractText
Effects of carbidopa, a dopa (3,4-dihydroxyphenylamine) decarboxylase inhibitor, on the renal, haemodynamic and hormonal responses to acute volume expansion were examined in six healthy mongrel dogs which were infused intravenously with 0.9% sodium chloride solution (saline; 30 ml h-1 kg-1) over 2 h. Saline infusion studies were performed in the absence (control) and in the presence of carbidopa given by nasogastric tube in a dose of 1 mg/kg every 8 h beginning 24 h before the infusion. Saline infusion resulted in an increase in renal excretion of dopamine (3,4-dihydroxyphenylethylamine) and a decrease in renal excretion of noradrenaline. Carbidopa treatment decreased urinary sodium excretion and eliminated the increase in renal production of dopamine in response to saline infusion without affecting renal or haemodynamic response to acute vascular volume expansion with saline. Carbidopa treatment obliterated the suppression of aldosterone produced by saline infusion. Thus, dopamine appears to play a significant role in mediating both the natriuretic and aldosterone response to acute volume expansion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0143-5221
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
263-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Dopaminergic regulation of natriuretic response to acute volume expansion in dogs.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.