Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1985-3-26
|
| pubmed:abstractText |
To evaluate the long-term hemodynamic results in cardiac transplant patients treated with cyclosporine and prednisone, 19 patients were studied by cardiac catheterization and endomyocardial biopsy 13 +/- 3 months after transplantation. Immunosuppression consisted of 6 +/- 4 mg/kg/day cyclosporine and 20 +/- 8 mg/day prednisone. Eighteen patients were asymptomatic but had developed postoperative systemic hypertension (17 on antihypertensive therapy). These patients were compared with a normotensive control group of 18 patients without cardiovascular disease. Significant differences were found in heart rate; right atrial, pulmonary arterial, pulmonary arterial wedge, systemic arterial, and left ventricular end-diastolic pressures; cardiac index and stroke volume index; systemic and pulmonary vascular resistance; and end-diastolic volume index and left ventricular ejection fraction. The most frequent hemodynamic abnormalities included an elevated arterial pressure in 10 patients (56%), an elevated left ventricular end-diastolic pressure in six patients (33%), and a reduced ejection fraction in five patients (28%). Hemodynamic abnormalities tended to resolve or improve in the five patients restudied 2 years after transplantation. There was no significant relationship between fibrosis or inflammation on endomyocardial biopsy and hemodynamic abnormalities. We conclude that mild-to-moderate hemodynamic abnormalities are common in asymptomatic cardiac transplant patients receiving cyclosporine and prednisone.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0009-7322
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
71
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
487-94
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3882266-Adult,
pubmed-meshheading:3882266-Biopsy,
pubmed-meshheading:3882266-Blood Pressure,
pubmed-meshheading:3882266-Cardiac Output,
pubmed-meshheading:3882266-Cyclosporins,
pubmed-meshheading:3882266-Endocardium,
pubmed-meshheading:3882266-Endomyocardial Fibrosis,
pubmed-meshheading:3882266-Female,
pubmed-meshheading:3882266-Graft Rejection,
pubmed-meshheading:3882266-Heart Catheterization,
pubmed-meshheading:3882266-Heart Rate,
pubmed-meshheading:3882266-Heart Transplantation,
pubmed-meshheading:3882266-Hemodynamics,
pubmed-meshheading:3882266-Humans,
pubmed-meshheading:3882266-Hypertension,
pubmed-meshheading:3882266-Male,
pubmed-meshheading:3882266-Middle Aged,
pubmed-meshheading:3882266-Myocardium,
pubmed-meshheading:3882266-Prednisone,
pubmed-meshheading:3882266-Prospective Studies,
pubmed-meshheading:3882266-Stroke Volume,
pubmed-meshheading:3882266-Time Factors,
pubmed-meshheading:3882266-Vascular Resistance
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Long-term hemodynamic follow-up of cardiac transplant patients treated with cyclosporine and prednisone.
|
| pubmed:publicationType |
Journal Article
|