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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1985-3-1
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pubmed:abstractText |
A chemically synthesized peptide (sequence in text) homologous to residues 61-83 of the HLA-B7 heavy chain, induced antibodies that specifically recognized the HLA heavy chain-beta 2-microglobulin complex and the free heavy chain of the HLA-B7 antigen. These antibodies specifically immunoprecipitated the HLA-B7 beta 2-microglobulin complex solubilized from human lymphoblastoid cells by nonionic detergents and reacted with free HLA-B7 heavy chains in blots on nitrocellulose. These observations suggest that the antigenic conformation of this region of the HLA-B7 molecule is independent of the presence of beta 2-microglobulin and that amino acid residues 61-83 mimic an alloreactive site expressed by the HLA-B7 antigen.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-388439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-4850204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-518865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-569916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-6165999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-6167991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-6168579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-6176330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-6179086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-6193808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-643051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-6452579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-6571999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-6577434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-6609813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-6934534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-7061871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-7461911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-84683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3881768-87477
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
539-42
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
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pubmed:year |
1985
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pubmed:articleTitle |
Human major histocompatibility complex class I antigens: residues 61-83 of the HLA-B7 heavy chain specify an alloreactive site.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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