Linked Life Data

3879797

Source:http://linkedlifedata.com/resource/pubmed/id/3879797

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-6
pubmed:dateCreated
1986-9-16
pubmed:abstractText
A Parkinson-like syndrome was produced in nonhuman primates and successfully reversed through transplantation of heterologous fetal mesencephalic brain tissue. Rigidity and bradykinesia were induced by the chronic administration of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Once the deficits were fixed, Macaca mulatta with well-developed Parkinson-like behavior received fetal mesencephalic cell preparations stereotactically implanted into multiple sites of the head of the caudate bilaterally. Both animals demonstrated a normalization of CSF L-dopa and significant improvement in observed activity. The neuropathological studies performed 2 months following transplantation demonstrated successful integration of fetal cells in the caudate.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0302-2773
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
358-61
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Preliminary report on the use of fetal tissue transplantation to correct MPTP-induced Parkinson-like syndrome in primates.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.