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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1986-2-18
|
| pubmed:abstractText |
Ocular clearance of amphotericin B after direct intravitreal injection was studied in a rabbit model. Unmodified phakic eyes, Candida-infected eyes, aphakic eyes, and aphakic vitrectomized eyes were employed. Using high pressure liquid chromatography to assess drug level, the half-lives of drug disappearance after single 10-microgram (microgram) intravitreal injections were 9.1, 8.6, 4.7, and 1.4 days, respectively. The disappearance slope for vitrectomized eyes was significantly different from all nonvitrectomized eyes with P less than 0.001. The rapid disappearance of amphotericin from vitrectomized eyes must be considered in clinical management of patients with fungal endophthalmitis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0161-6420
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
92
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1601-5
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3878487-Amphotericin B,
pubmed-meshheading:3878487-Animals,
pubmed-meshheading:3878487-Candidiasis,
pubmed-meshheading:3878487-Endophthalmitis,
pubmed-meshheading:3878487-Half-Life,
pubmed-meshheading:3878487-Kinetics,
pubmed-meshheading:3878487-Rabbits,
pubmed-meshheading:3878487-Reference Values,
pubmed-meshheading:3878487-Vitrectomy
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Amphotericin clearance in vitrectomized versus nonvitrectomized eyes.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|