|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0003261,
umls-concept:C0011306,
umls-concept:C0021013,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0034493,
umls-concept:C0040333,
umls-concept:C0442818,
umls-concept:C0679727,
umls-concept:C1627358,
umls-concept:C1947910,
umls-concept:C2349975
|
|
pubmed:issue |
23
|
|
pubmed:dateCreated |
1986-1-6
|
|
pubmed:abstractText |
The role of splenic lymphoid dendritic cells (DC) and macrophages (M phi) from mice in induction of immune responses in vivo has been investigated. Varying numbers of purified DC and M phi pulsed in vitro with tobacco mosaic virus (TMV) or with rabbit antiidiotypic antibodies (Ab2) directed against a private rabbit anti-TMV idiotype were injected back into syngeneic mice. In both systems, DC appeared to strongly enhance the primary and secondary responses to the virus. Optimal responses were obtained with 5 X 10(4) purified DC carrying TMV or rabbit Ab2. In contrast, M phi were less efficient by a factor of at least 100. These results show the potency of lymphoid DC as inducing cells in T-dependent antibody responses in vivo.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-154105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-270748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-303775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-312906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-313747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-3156000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-3884274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-4589990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-6185614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-6189941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-6206192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-6227678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-6228574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-6239901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-6300278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-6333484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-6351074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-6445399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-6460641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-6461712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-6576348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-6609192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-6968335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-6980123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-7356727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-762493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877936-85681
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
82
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
8149-52
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:3877936-Animals,
pubmed-meshheading:3877936-Antibodies, Anti-Idiotypic,
pubmed-meshheading:3877936-Antibodies, Viral,
pubmed-meshheading:3877936-Antibody Formation,
pubmed-meshheading:3877936-Antigen-Presenting Cells,
pubmed-meshheading:3877936-Immunoglobulin Idiotypes,
pubmed-meshheading:3877936-Immunologic Memory,
pubmed-meshheading:3877936-Macrophages,
pubmed-meshheading:3877936-Mice,
pubmed-meshheading:3877936-Rabbits,
pubmed-meshheading:3877936-Spleen,
pubmed-meshheading:3877936-Tobacco Mosaic Virus
|
|
pubmed:year |
1985
|
|
pubmed:articleTitle |
Enhancement of antibody response by mouse dendritic cells pulsed with tobacco mosaic virus or with rabbit antiidiotypic antibodies raised against a private rabbit idiotype.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
