| pubmed-article:3877778 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3877778 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:3877778 | lifeskim:mentions | umls-concept:C0034789 | lld:lifeskim |
| pubmed-article:3877778 | lifeskim:mentions | umls-concept:C0034805 | lld:lifeskim |
| pubmed-article:3877778 | lifeskim:mentions | umls-concept:C0031621 | lld:lifeskim |
| pubmed-article:3877778 | lifeskim:mentions | umls-concept:C0034788 | lld:lifeskim |
| pubmed-article:3877778 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:3877778 | lifeskim:mentions | umls-concept:C1157950 | lld:lifeskim |
| pubmed-article:3877778 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:3877778 | pubmed:dateCreated | 1986-1-23 | lld:pubmed |
| pubmed-article:3877778 | pubmed:abstractText | F(ab')2 fragments of rabbit anti-mouse Ig induce proliferation of murine B lymphocytes, whereas the intact antibodies are not mitogenic. F(ab')2 anti-Ig stimulates the rapid breakdown of inositol phospholipids in B cells, resulting in the prolonged release of inositol (poly)phosphates and diacylglycerol. In marked contrast, intact anti-Ig initially induces a comparable response, which is abrogated after some 30 s. Blocking either the Fc receptors on the B cells or the Fc portion of the antibodies significantly reversed the inhibitory effect. On the other hand, both forms of anti-Ig elicited comparable increases in free cytoplasmic Ca2+ levels in B cells. These results therefore indicate that crosslinkage of Fc and surface Ig receptors on B cells inhibits inositol phospholipid breakdown (but not Ca2+ flux) resulting from ligation of the antigen receptors. Since there is evidence implicating inositol phospholipid breakdown in the induction of cell growth, this effect could provide a biochemical explanation for the known capacity of antigen-antibody complexes to inhibit B cell activation. | lld:pubmed |
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| pubmed-article:3877778 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3877778 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3877778 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3877778 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3877778 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:3877778 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:3877778 | pubmed:author | pubmed-author:KlausG GGG | lld:pubmed |
| pubmed-article:3877778 | pubmed:author | pubmed-author:BijsterboschM... | lld:pubmed |
| pubmed-article:3877778 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3877778 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:3877778 | pubmed:volume | 162 | lld:pubmed |
| pubmed-article:3877778 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3877778 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3877778 | pubmed:pagination | 1825-36 | lld:pubmed |
| pubmed-article:3877778 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3877778 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3877778 | pubmed:articleTitle | Crosslinking of surface immunoglobulin and Fc receptors on B lymphocytes inhibits stimulation of inositol phospholipid breakdown via the antigen receptors. | lld:pubmed |
| pubmed-article:3877778 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3877778 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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