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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1985-11-27
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pubmed:abstractText |
The effect of antigen-specific antibodies on the response of human T-cell lines and clones to rabies virus was studied. Plasmas from rabies-immune vaccine recipients, but not those from nonimmune individuals, enhanced the proliferative response of rabies-reactive T cells to whole inactivated virus or to the purified glycoprotein and nucleocapsid from the rabies virion. Rabies-immune plasma also increased the antigen-induced production of gamma interferon by the rabies-specific T-cell lines. Experiments performed on T-cell clones specific for either rabies glycoprotein or nucleocapsid showed that immune plasma as well as antiglycoprotein and antinucleoprotein murine monoclonal antibodies possessed the capacity to increase significantly the antigen-induced proliferative responses of these clones. The overall results indicate that this in vitro effect of antigen-specific antibodies on the response of regulatory T lymphocytes to rabies virus could be an important factor in the development of effective immune responses in vivo to rabies virus.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-1085419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-13987706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-14106299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-14978857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-386386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-404363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-4542608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-4542806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-4874538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-5165090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-6155432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-6155436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-6231724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-6242349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-6242466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-6399980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-6436821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-6712036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-6778924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-6823748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3877176-6972044
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
426-33
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3877176-Antibodies, Viral,
pubmed-meshheading:3877176-Antigen-Presenting Cells,
pubmed-meshheading:3877176-Antigens, Viral,
pubmed-meshheading:3877176-Capsid,
pubmed-meshheading:3877176-Clone Cells,
pubmed-meshheading:3877176-Glycoproteins,
pubmed-meshheading:3877176-Humans,
pubmed-meshheading:3877176-Lymphocyte Activation,
pubmed-meshheading:3877176-Protein Denaturation,
pubmed-meshheading:3877176-Rabies,
pubmed-meshheading:3877176-Rabies Vaccines,
pubmed-meshheading:3877176-Rabies virus,
pubmed-meshheading:3877176-T-Lymphocytes,
pubmed-meshheading:3877176-Viral Core Proteins,
pubmed-meshheading:3877176-Viral Proteins
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pubmed:year |
1985
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pubmed:articleTitle |
Amplification of rabies virus-induced stimulation of human T-cell lines and clones by antigen-specific antibodies.
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pubmed:publicationType |
Journal Article
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