pubmed-article:3876184 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:3876184 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:3876184 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
pubmed-article:3876184 | lifeskim:mentions | umls-concept:C0814999 | lld:lifeskim |
pubmed-article:3876184 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:3876184 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:3876184 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:3876184 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:3876184 | pubmed:dateCreated | 1985-10-30 | lld:pubmed |
pubmed-article:3876184 | pubmed:abstractText | By panning procedures employing T6 and T3 monoclonal antibody, human thymocytes were fractionated into two subpopulations depleted of T6- or T3-positive (T6+, T3+) cells. Unfractionated thymocytes and T6- and T3-depleted subpopulations were separately cultured for 48 h in RPMI 1640 medium with 10% FCS or in HB 101 serum-free medium. Determining the phenotype of unfractionated thymocytes at various time intervals, a time-dependent increase of T3+ cells was observed. An inverse relationship was found between the percentage of T3+ cells and the T6 and peanut agglutinin (PNA) reactive thymocytes. When the surface antigen expression in the T3-depleted population (greater than 95% T6+ and PNA+ cells) was analysed, a strong increase of T3+ cells and a complementary reduction of T6+ and PNA+ cells was evidenced. During that time the surface phenotype of the T6-depleted population (greater than 80% T3+ cells) showed the same trend of differentiation, as the other thymocyte preparations. These results indicate that a conspicuous fraction of human thymocytes and particularly of those characterized by a cortical phenotype (PNA+ and T6+ cells), are able to express mature T-cell antigens when cultured in vitro in the absence of the thymic microenvironment influence. However, the in vitro acquisition of a mature phenotype is not accompanied by a parallel achievement of the capacity to respond to mitogens such as PHA or T3 monoclonal antibody. | lld:pubmed |
pubmed-article:3876184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:3876184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:language | eng | lld:pubmed |
pubmed-article:3876184 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:3876184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3876184 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:3876184 | pubmed:month | Aug | lld:pubmed |
pubmed-article:3876184 | pubmed:issn | 0009-9104 | lld:pubmed |
pubmed-article:3876184 | pubmed:author | pubmed-author:MusianiPP | lld:pubmed |
pubmed-article:3876184 | pubmed:author | pubmed-author:PiantelliMM | lld:pubmed |
pubmed-article:3876184 | pubmed:author | pubmed-author:MaggianoNN | lld:pubmed |
pubmed-article:3876184 | pubmed:author | pubmed-author:LaroccaL MLM | lld:pubmed |
pubmed-article:3876184 | pubmed:author | pubmed-author:AielloF BFB | lld:pubmed |
pubmed-article:3876184 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:3876184 | pubmed:volume | 61 | lld:pubmed |
pubmed-article:3876184 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:3876184 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:3876184 | pubmed:pagination | 433-9 | lld:pubmed |
pubmed-article:3876184 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:3876184 | pubmed:year | 1985 | lld:pubmed |
pubmed-article:3876184 | pubmed:articleTitle | T3 expression by human thymocytes in culture. | lld:pubmed |
pubmed-article:3876184 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:3876184 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |