Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1985-10-24
pubmed:abstractText
One hundred and forty-one patients with rheumatoid arthritis treated with aurothiopropanol sulphonate or D-penicillamine, or both were examined for HLA antigens to investigate the genetic influence on the occurrence of different adverse reactions during therapy. All 13 patients possessing HLA-DR3 had toxic reactions. The relative risk for DR3 positives of developing skin eruptions or proteinuria was calculated to be 10.5 times and seven times respectively that of DR3 negatives. The incidence of DR7 antigen in 94 patients with toxic reactions was significantly decreased (11% compared with 28% in controls) suggesting a protective role for this antigen.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3876081-147420, http://linkedlifedata.com/resource/pubmed/commentcorrection/3876081-6193576, http://linkedlifedata.com/resource/pubmed/commentcorrection/3876081-6234391, http://linkedlifedata.com/resource/pubmed/commentcorrection/3876081-6376799, http://linkedlifedata.com/resource/pubmed/commentcorrection/3876081-6402993, http://linkedlifedata.com/resource/pubmed/commentcorrection/3876081-6415865, http://linkedlifedata.com/resource/pubmed/commentcorrection/3876081-6420562, http://linkedlifedata.com/resource/pubmed/commentcorrection/3876081-6430303, http://linkedlifedata.com/resource/pubmed/commentcorrection/3876081-6610749, http://linkedlifedata.com/resource/pubmed/commentcorrection/3876081-6770269, http://linkedlifedata.com/resource/pubmed/commentcorrection/3876081-6787722, http://linkedlifedata.com/resource/pubmed/commentcorrection/3876081-6934774, http://linkedlifedata.com/resource/pubmed/commentcorrection/3876081-6942668, http://linkedlifedata.com/resource/pubmed/commentcorrection/3876081-6959574, http://linkedlifedata.com/resource/pubmed/commentcorrection/3876081-719380
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents, http://linkedlifedata.com/resource/pubmed/chemical/Dimercaprol, http://linkedlifedata.com/resource/pubmed/chemical/Gold, http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens, http://linkedlifedata.com/resource/pubmed/chemical/HLA-A Antigens, http://linkedlifedata.com/resource/pubmed/chemical/HLA-B Antigens, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR3 Antigen, http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II, http://linkedlifedata.com/resource/pubmed/chemical/Organogold Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Organometallic Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Penicillamine, http://linkedlifedata.com/resource/pubmed/chemical/Propanols, http://linkedlifedata.com/resource/pubmed/chemical/Sulfhydryl Compounds, http://linkedlifedata.com/resource/pubmed/chemical/aurotioprol
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0003-4967
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
621-4
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:3876081-Adult, pubmed-meshheading:3876081-Aged, pubmed-meshheading:3876081-Anti-Inflammatory Agents, pubmed-meshheading:3876081-Arthritis, Rheumatoid, pubmed-meshheading:3876081-Dimercaprol, pubmed-meshheading:3876081-Female, pubmed-meshheading:3876081-Gold, pubmed-meshheading:3876081-HLA Antigens, pubmed-meshheading:3876081-HLA-A Antigens, pubmed-meshheading:3876081-HLA-B Antigens, pubmed-meshheading:3876081-HLA-DR3 Antigen, pubmed-meshheading:3876081-Histocompatibility Antigens Class II, pubmed-meshheading:3876081-Humans, pubmed-meshheading:3876081-Male, pubmed-meshheading:3876081-Middle Aged, pubmed-meshheading:3876081-Organogold Compounds, pubmed-meshheading:3876081-Organometallic Compounds, pubmed-meshheading:3876081-Penicillamine, pubmed-meshheading:3876081-Propanols, pubmed-meshheading:3876081-Sulfhydryl Compounds
pubmed:year
1985
pubmed:articleTitle
HLA antigens and toxic reactions to sodium aurothiopropanol sulphonate and D-penicillamine in patients with rheumatoid arthritis.
pubmed:publicationType
Journal Article