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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1985-10-22
|
| pubmed:abstractText |
120 consecutive clinical isolates of various species of Enterobacteriaceae and 30 consecutive clinical isolates of Haemophilus influenzae (including 5 which produced beta-lactamase) were assessed for susceptibility to temocillin using a broth microdilution technique and both 'light' (10(3) CFU/ml) and 'heavy' (10(6) CFU/ml) inocula. At the lighter inoculum, 90% of the Enterobacteriaceae were inhibited by temocillin at a concentration of 4 mg/L. 90% of the H. influenzae were similarly inhibited at a concentration of 0.5 mg/L, and no differences were observed between producers and non-producers of beta-lactamase. At the heavier inoculum, a significant inoculum effect was observed: minimum inhibitory concentrations (MICs) increased up to 128-fold for H. influenzae and somewhat less than that for the Enterobacteriaceae. Klebsiella pneumoniae was least affected by inoculum, showing only a 2- to 4-fold increase in the MIC. It is concluded that temocillin is active in vitro against the species tested and warrants further clinical trial.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0012-6667
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29 Suppl 5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
15-7
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| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading | |
| pubmed:year |
1985
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| pubmed:articleTitle |
In vitro activity of temocillin against gram-negative clinical isolates.
|
| pubmed:publicationType |
Journal Article
|